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side effects vpxl The success of edoxaban compared to warfarin is good news in the quest for simplified treatment of VTE, said Dr. Büller. "The problem with warfarin is that food and alcohol and many, many medications interfere with the level and so therefore you're obliged to do careful laboratory testing every 3 to 4 weeks or even more frequently to measure the INR (international normalised ratio) and adjust the dose," he said. "The great advantage of the new oral anticoagulants is they have very predictable kinetics and dynamics and therefore can be given in a fixed dose and do not need monitoring."
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