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perfect design thanks topamax 75 mg twice a day Oftentimes, precisely because they know they struggle in the later parts of the day, they keep their daytime calories purposely low and even intentionally skip meals; their rationale being, given their known calorie excesses at night, they're better off not to eat many calories in the day. In turn, this sets up a recurrent pattern of binging or binge-like behaviors at night, which may further spike ghrelin's trained secretion.